Carolina Panthers vs San Francisco 49ers Prediction: 49ers will pick up a win in this match

During week five of the NFL season, the Carolina Panthers will host the San Francisco 49ers at SoFi Stadium late on a Sunday evening. After Monday's 24-9 home victory over the Los Angeles Rams, the 49ers will be primed to take a win in this match. Meanwhile, Carolina is hoping to bounce back from a disappointing setback of 16-26 to the Cardinals.

The Carolina Panthers have failed to win any of their last eight games played at home in a row. Baker Mayfield has a completion percentage of 54.7 per cent, with 747 yards, four touchdowns, and three interceptions from his passing attempts. Robbie Anderson, DJ Moore, and Christian McCaffrey have all contributed receptions, and the three of them have combined for 312 receiving yards and two touchdowns. McCaffrey is leading the way for the Carolina Panthers' ground game with 270 yards and one score, and the team's rushing average is currently at 96.3 yards per game. Carolina's defense is currently giving up an average of 346 yards and 21.3 points per game. Frankie Luvu has the most tackles (32), Brian Burns has the most sacks (3), and Derrick Brown has the most interceptions (1) for the Carolina Panthers.

The 49ers have gone on the road eight times in a row, won four, lost four, and tied two. Jimmy Garoppolo has a passer rating of 61. He has completed 604 passes for 604 yards, three touchdowns, and one interception. Deebo Samuel, Brandon Aiyuk, and Jauan Jennings have all caught passes for the team, and the three of them have combined for 425 receiving yards and two touchdowns. The San Francisco 49ers have a 135.3-yard-per-game rushing average, with Jeff Wilson Jr. accounting for 255 yards and one touchdown. San Francisco's defense is giving up an average of 234.5 yards and 11.5 points per game. The San Francisco 49ers are led defensively by Dre Greenlaw with 38 tackles, while Nick Bosa has six sacks and Talanoa Hufanga has two interceptions, contributing significantly to the attack. The 49ers are 6-2 against the spread in their past eight games and 6-1 against the spread in their previous seven versus National Football Conference teams.

This is the first meeting between the two teams since the 49ers' 51-13 thumping of the Raiders on October 27, 2019, at Levi's Stadium in Santa Clara. Before that match, both previous matches had been won by Carolina. The Panthers are 5-2 against the spread in the last seven encounters dating back to December 2, 2007, while the Under is 4-2. Given that the 49ers are playing on a short week, the Carolina Panthers are a decent home underdog. However, the Panthers haven't done much on defense or offense, and playing at home hasn't helped much since last season. The San Francisco 49ers put pressure on opposing quarterbacks and rank among the league's strongest defensive units. The Niners are favored to win.

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